Clinical Significance Of Microvessel Density And Nm23,VEGF Protein Expression In Gastric Carcinoma

Objective:To determine the microvessel density (MVD) and the expression of nin23. VEGF gene protein in gastric carcinomas and its relationship to the genesis, the development and prognosis of the tumer , to evaluate the predictive value of them. Methodes: nm23, VEGF protein expression and MVD in 98 cases of human gastric carcinoma were examined inminohistochemically by using anti-nm23, anti-Ⅷ factor uxnoclonal antibody and anti梀EGF, antibody,respectively. The relationships between the results and clinicopathological features were studied. Statistical methods were used to detect the significance. Results: l.Postive staining rate of nm23 in human gastric carcinoma was 57%. Nm23 positively correlated with histologic types (p<0.05), depth of invasion (p<0.05), lymph node metastasis (p<0.01) and prognosis(p<0.01), but their relation to the age and gender was not significant. 2. Positive staining rate of VEGF in human gastric carcinoma was 45.9%.MVL) was significantly higher in VEGF-positive gastric carcinoma than in VEGF-negative gastric carcinoma(p<0. 01). MVD and VEGF positively correlated with depth of invasion(p<0.01),lymph node metastasis (p<0. 05), but their relation to the histologic types of gastric carcinoma and age and gender was not significant. Patients with VEGF-positive gastric carcinoma had a significantly poorer prognosis than those with VEGF-negative ones (p<0. 05). 2 Conclusion:The expression of nm23 in gastric carcinoma play an important role in suppression of growth invasion and metastasis of tumor. VEGF is highly related to angiogenesis of gastric carcinoma and promotes growth, invasion and metastasis of tumor. Detection of MVD and nm23. VEGF protein expression may be useful in assessing the development, judging prognosis and selecting clinical therapy.