Regulation Of Immune Response In Essential Hypertension And The Possible Mechanism Of Antihypertensive Drugs Effect

Aim To investigate the changes of immune function in varying degrees of hypertension and the effects of calcium antagonists (CaA) and angiotensin converting enzyme inhibitors (ACEI) on dysfunction of immune system in essential hypertension (EH). Method The serum immunoglobulin and complement levels were measured by immunoturbidimetrv. Total T and T cell subsets were detezminted by direct method, and interleukin-2 (IL-2). interleukin -4(IL-4) levels were measured by enzyme linked-immuno. sorbent assay in 62 individuals. At the same time to evaluate the effect of CaA and ACEI on these changes respectively. Results There were significant difference in IgG. C3. CD4. CD4/CD8 and IL-2 between EH patients with or with out left ventricular hypertrophy (LVH). ACEI could significantly reduce levels of IgG . C3. CD3. CD4. CD4/CD8 and obviously improve CD8 level after 12 weeks of treatment, meanwhile CaA could significantly reduce the levels of IgG.C3. CD4/CD8 and obviously improve CD8 level after 12 weeks of treatment. Conclusion The changes of immune system function were different according to the degrees of EH; CaA and ACEI could reduce blood pressure (BP), re~ erse LVH and these effects were correlated with regulation of immunologic dysfunction.