Proton Magnetic Resonance Spectroscopy Of Temporal Lobe Epilepsy

We studied the Proton Magnetic ResonanceSpectroscopy('HMRS) findings of temporal lobe epilepsy(TLE)patients to find metabolic abnormalities in temporal lobe and todetermine the relative utility of *HMRS in lateralization theseizure focus in patient with TLE.Methods !HMRS, MRJ and EEC were performed on 14patients with TLE(12 with lateral seizure focus and 2 withbilateral seizure focuses). The values of NAA, CR and CHOwere calculated by integration of their peaks and the ratios ofNAA/CR+CHO, NAA/CR and CHO/CR were measured. Theresult of 'HMRS were compared with MRI and EEG.Results In 12 TLE patients with lateral seizure focus, theratios of NAA/CR+CHO, NAA/CR and CHO/CR on focus sidewere 0.67, 1.68 and 1.50, and the other side were 0.79,1.89 and1.39 separately. The ratios of NAA/CR+CHO and NAA/CR were decreased on focus side (t=3.2,2.3 separately, P<0.05). Based on the value of NAA/CR+CHO 10 cases were lateralized in accordance with EEG and 2 cases were not. One case with bilateral seizure focuses on EEG and significant temporal lobe atrophy on MRI didn't have satisfactory 'HMRS result. Conclusion 'HMRS can provide important metabolic information for localization in the patients with TLE. The combination of 'HMRS, MRI and EEG can provide useful information for diagnosis of TLE.