Clinical Parameters Of Primitive Neuroectodermal Tumor And Its Relationship With The Prognostic Outcome

Objectiveprimitive neuroectodermal tumors is one of the most frequent brain tumors in children. Characteristics of the patient is small age, short term, occurs in each part of the brain mostly on posterior fossa. Due to it grow very fast, compeletly removing is difficult, easy to recurrence, and seperated with CSF, therapy is very difficult. Though recently combined treatment proved prognostic outcomes, survivors are often confronted with serious late sequelae, caused by the therapy, affect their quality Of life. Therefore, prognostic markers must be identified to assign the different treatment schedules according to the predicted outcome.Patients and methodsThe medical data of 55cases with a medulloblastoma or central primitive neuroectodermal tumor(PNET),that were admitted to the Department of neurosurgery of Tianjin Medical University GeneralHospital, were analyzed by univariate and multivariate analyses.ResultsIn univariate the following Characteristics was analysed significant influence on progression free survival (PFS): (a) age at diagnosis (b) sex (c) extent of resection (d) analyzed by Chang staging system (e) the presence of metastases (f) analyzed by Roger Stratification (g) radiation dose (h) chemotherapyOn multivariate analysis only the presence of metastases and the radiation dose and extent of resection retained significance.ConclusionThough we got some clinical prognostic markers, there are a lot of patients do not fall into this category. So we feel it is necessary to research from molecular biology, to find reliable predictors.