The Study On The Effects Of Acute Large Amounts Of Alcohol Ingestion On Hemodynamics And Myocardial Mechanics In Dogs

Objectives: Alcohol has been a beverage for several thousand years. The association of excessive alcohol consumption with heart disease has fascinated cardiologists and cardiovascular scientists for more than 100 years. Numerous clinical and scientific studies that focus on this association and attempt to delineate its pathophysiologic basis have been performed. However, in many ways, the interaction of alcohol with the cardiovascular system are diverse, complex, and at times the results seem paradoxical. We designed this study to disclose the effects of large amounts of alcohol ingestion on hemodynamics and myocardial mechanics in healthy adults dogs in order to give some suggestion for both the diagnosis and the therapy.Methods: Catheter was put into left ventricle and Swan-Ganz catheter was put into pulmonary artery and right ventricle, and the third catheter was put into right femoral artery in ten dogs. Hemodynamic parameters and myocardial mechanical parameters were measured before alcohol ingestion and after alcohol ingestion 0.5h, Ih, 1.5h, 2.5h. At the same time, blood alcohol and some chemical substance was assayed.Results: After alcohol ingestion, multiple hemodynamic parameters of left and right ventricular systolic pressure, artery systolic pressure, mean pulmonary artery pressure and cardiac output were decreased, and left and right ventricular diastolic pressure and artery diastolic pressure were increased (P<0.05 ) . Heart rate was increased after alcohol ingestion (PO.05) . Myocardial mechanical parameters of the first derivative of left ventricle (?dp/dt), the maximal velocity of shortening of the contractile element (Vmax) were decreased, and the time constant of left ventricle pressure fall during isovolumic relaxation (T) was lengthened after alcohol ingestion (PO.05) . The plasma levels of vasoactive3substances such as catecholamine, renin, angiotensin- II were rised after alcohol ingestion (P<0.05) . PH, PaO2 were decreased and PaCO2 was increased after alcohol ingestioii (PO.05) .Conclusion: 1 .Alcohol interfered with sympathetic system and renal renin-angiotensin system. 2. Large amounts of alcohol ingested decreased both of the left ventricular systolic and diastolic function. 3. Large amounts of alcohol ingested leaded to metobolic acidosis.