Influence Of Temporary Occlusion Of Hepatic Venous On Drug Concentration In Portal Vein By Different Ways Of Drug Giving

Purpose: By analyzing the changes of pharmacokinetis in portal vein(PV),this article investigates the value of transcatheter chemotherapy through superior mesenteric artery(SMA)and hepatic artery (HA) when hepatic venous(HV) is temporally occluded. Materials and methods: Six dogs were performed four groups of experiments respectively and subject contrasts. A: transcatheter infusion of 5-Fu by SMA with HV occlusion (SMAI-THVO). B: only transcatheter infusion of 5-Fu through SMA(SMAI). C: infusion of 5-Fu through HA with HV occlusion(TAI-THVO). D: only infusion of 5-Fu through HA (TAI). Each group was drawn 5ml blood from PV on different time point (post- infusion: 0.5, 5, 10, 15, 20, 30 minutes). The high performance liquid chromatograph (HPLC) was employed to measure the blood concentration of 5-Fu in PV, and the changes of post-occlusion angiograph were analyzed. Results: The peak concentration (Cm) of 5-Fu of occlusion groups (A and C) and the area under the curve (AUC) of 5-Fu were greater than those in control groups (B and D), which was A>B>OD (P<0. 05). Sum of values of clearance in occlusion groups (A and C) were lower than those in control groups (B and C), which was A