The Clinical Research Of The Variation Of FSH,LH,PRL GH Concentration Of Serum In Patients With Ruptured Intracranial Aneurysms

Objective: The patients with ruptured intracranial aneurysms were investigated, and the serum concentration of FSH, LH, PRL, GH were measured, through which to explore the relationship between the concentration of FSH, LH, PRL, GH and the severity of symptom and the volume of hemorrhage and the change of symptom.Methods: 35 cases of ruptured intracranial aneurysms were studied. All the patients who had subarachnoid hemorrhage were confirmed by CT and diagnosed by DSA as intracranial aneurysms. The volume of subarachnoid hemorrhage was evaluated according to Fisher CT grade, the severity of symptom was evaluated according to Hunt and Hess grade. The venous blood of all these patients were got during 1-3 days after intracranial aneurysms ruptured (acute phase). The indexes of 11 cases were measured continuously, their blood were got again during 7-9 days and 13-15 days after intracranial aneurysms ruptured. All the blood were centrifuged to get serum. The samples were measured together. Using chemiluminescence immunoassay to measure FSH, LH, PRL, using radioimmunoassay to measure GH, then we observed the concentration variation.Result: During acute phase (1) the relationship between the indexes and the volume of hemorrhage: the difference of the indexes were not significant between Fisher CT I, II grade patients and those of the controls, (P>0.05); the difference of the indexes between Fisher CT III, IV grade patients and those of the controls was significant, (P<0.05). The averages of FSH, LH, PRL, GH of Fisher CT IV grade patients increased by 3 times, 9 times, 2.5 times, 2.5 times as compared with the controls. The difference of the indexes was not significant between Fisher CT I grade patients and those of FisherCT II grade, (P>0.05); Compared with Fisher CT I grade patients, the indexes of Fisher CT III, IV grade patients were significantly different (P<0.05). (2) the relationship between the indexes and severity of symptom: comparing with those of Hunt I grade patients, all the indexes of Hunt II grade patients were not significantly different(P>0.05), the indexes of Hunt III-V grade patients were significantly different(P<0.05). The averages of FSH, LH, PRL,GH of Hunt IV-V grade patients increased by 3 times, 5 times, 2.5 times, 2.5 times as compared with the Hunt I grade patients. (3) Continuous measurement of the indexes during different phases: All the indexes in 1-3 days, 7-9 days after intracranial aneurysms ruptured were significantly different compared with those of the controls, P<0.05. The indexes of 7-9 days after intracranial aneurysms ruptured were most significant, their averages of FSH, LH, PRL, GH increased by 4 times, 6 times, 3 times, 3 times as compared with those of the controls. The indexes between 1-3 days after intracranial aneurysms ruptured and those of 7-9 days, the indexes between 7-9 days after intracranial aneurysms ruptured and those of 13-15 days were significantly different, P<0.05.Conclusions: The indexes of FSH, LH, PRL, GH of serum in patients with ruptured intracranial aneurysms were positively correlated with the volume of hemorrhage: the more hemorrhage, the higher these indexes. The difference of the indexes was significant between Fisher CT III, IV grade patients and those of Fisher CT I, the controls, these findings suggest that there be a positive correlation between the volume of hemorrhage and the extent of damage to hypothalamic-pituitary axes. With the increase of Hunt grade, the increase of indexes was more obvious. The significant difference of indexes between Hunt III, IV-V grade patients and those of Hunt Isuggest that the indexes correlate with the severity of symptom. Continuously measured indexes explored that the indexes of different phases increased significantly. The differences were significant between the indexes of different phases and those of the controls. The indexes of 7-9 days after intracranial aneurysms ruptured increased remarkably. The indexes between 7-9 days after intracranial aneurysms ruptured and those of 1-3 days,...