Experimental Study Of SanXue MingMu TABLET On PVR Induced By Hemorrhage And Protecting Retina

Objective: To observe the effects of SanXue MingMu Tablet (SXMMT) on cleaning experimental vitreous hemorrhage of rabbits, and investigate its effects and mechanism on Proliferative Vitreoretinopathy (PVR) induced by vitreous hemorrhage and protection on retina.Methods:30 rabbits were selcted randomly from 40 rabbits and developed into models with of vitreous hemorrhage of rabbits' right eyes by autoblood, then divided randomly into three groups: the first treatment which group was treated with traditional Chinese medicine SXMMT, the second treated group with XueSaiTong Tablet (XSTT) and the model group. The rest 10 formed the blank control group. After the rabbits had been fed and administrated for four weeks, we observed the visibility of fundus, the incidence of PVR and pathologic changes, measured the levels of intrleukin-6 (IL-6) and tumor necrosis factor (TNF-a) in vitreous. Eight weeks later, we observed those again.Results: After four weeks, the visibility of fundus changed little in allvitreous hemorrhage groups. The IL-6 levels in model control group and SXMMT group were significantly higher than those in XSTT group or blank group(p<0.01 or p<0.05), there was no significant difference between the model control group and SXMMT group(p>0.05). The TNF-a levels in model control group and SXMMT group were significantly higher than those in XST group and blank group(p<0.01 or p<0.05), there was significant difference between the model control group and SXMMT group(p<0.05). After eight weeks, we observed that the vitreous in SXMMT group liquefied evidently, the hemorrhage also was absorbed evidently, and cellulation could been observed in vitreous. PVR was lighter than that in XST group and model group (p<0.05). The levels of IL-6 and TNF-a in SXMMT group were evidently lower than those in model group, and had highly significant difference (p<0.01), and there was no significant change compared with those in blank group (p>0.05).Conclusions: 1. SXMMT could evidently accelerate vitreous liquefaction and absorption of vitreous hemorrhage, the mechanism was probably related to that SXMMT could promote macrophage's phagocytosis, it might play an important role in accelerating absorption of vitreous hemorrhage.2. SXMMT could decrease the levels of IL-6 and TNF-a released by macrophage, inhibit their high expression in vitreous, and impede the incidence and development of PVR.3. SXMMT has protective effects on retina.