The Study On The Mechanism Of Acute Cerebral Infarction In Rats With The Therapy Of Herbal Medicine Huonaokang

In this subject, the male rats of Wistar strain were selected as experimental study objects. 30 rats were divided into three groups by random: false operation group (group A), model group(group B). therapy group(group C).To anologue the pathologic change coursed by cerebral ischemia in human, the animal model were made by blocking middle cerebral artery.Neuronal function evaluation, halter test, rotation test, reticular screen test,pathomorphologic charge, cell apoptosis and NO NOS in plasma were selected as indexes. We contrasted the difference among different groups at 24 hours, 5 day and 10 day after the operation and tried to show the mechanism of herbal medicine therapy in acute cerebral infarction from the scopes of behavior medicine pathomorphology and biochemistry.The study showed that herbal medicine therapy can improve cerebral infarct rat's grasping equilibrating, moving function and strengthen myodynamia; improve glia cell and collagenons fibers hyperplasia and reduce cerebral tissue edema and infarct size.Restrain cell apoptosis lighten the injure of infarction.The study proved that the therapy of herbal medicine can reduce ischemic cell damage and delay programed cell death or apoptosis after cerebral infarction. It can protect and repair neuron. This experiment provided theoretical basis to clinic.