Clinical Significance Of Soluble L-selectin Level Of Cerebrospinal Fluid In Patients With Central Nervous System Leukemia

Objective: To investigate the role and clinical significance of soluble L-selectin(sL-selectin) level of cerebrospinal fluid(CSF) to the occurrence and progress of central nervous system leukemia (CNSL).Methods: Both 25 leukemia patients without CNSL and 17 with CNSL were performed lumbocentesis to obtain CSF for detection of sL-selectin level by enzyme- linked immunosorbant assay(ELISA).Results: sL-selectin level of CSF in patients with CNSL were significantly higher than in those with no CNSL(180.38±196.95 ng/ml vs 38.09 ±59.44ng/ml; p<0.05) ; furthermore in the 10 of the patients with CNSL who got complete remission (CR) after chemotheraphy, sL-selectin level were obviously decreased after treatment(355.44± 454.04 ng/ml vs 66.52 ±123.63ng/ml; p<0.01); sL-selectin level of the other 7 of those who got partialremission(PR) or no remission(NR) had no statistical difference between pre-treatment and pro-treatment(102.22 ±114.05 ng/ml vs 85.23 ±76.46ng/ml;p>0.05). The average sL-selectin level in those who got CR were seemingly higher than in those who got PR or NR, but there were no statistic differences.Conclusions: sL-selectin participates the procedure of theoccurrence and progress to CNSL and sL-selectin level may be a marker to early diagnosis of CNSL, but the relationship between sL-selectin before treatment and the therapeutic effect is undetermined, as need to be further studied.