| Ilex Kudingcha C.J. Tseng is a plate of Aquifoliaceae. It's Chinese herbal medcine ordinary used in the south of China. Generally, its folia are used for medcine. It has the functions of clear away heat and toxic materials, help produce saliva and slake thirst, promote blood circulation, refresh oneself and strengthen the brain, regulation of blood pressure and blood fat. This paper is to study the vasodilative effect of Kudingcha Total Saponin (KDC-TS) and to inquire into its mechanism.The results indicate that: KDC-TS can decrease the stroke index score of carebral ischemia mice, significantly prolong the life time of mice -bilateraled ligation of common carotid arteries with vagus nerves, dilate mice auriculae arteriolan and venular diameter, KDC-TS(165, 82.5 ug-L"1) shifted the concentration-response curves of noradrenaline (NA) and CaCl2 to the right, and depressed their maximal reoponses, while KDC-TS (165 ug-L-1) was found have no effect on the concentration-response curve of KC1, KDC-TS(165, 82.5, 41.2 ug-L-1) inhibited the extracellular Ca2+dependent component of NA induced contraction of the rabhit aortic strips, but KDC-TS(165, 82.5, 41.2 ug-L-1) had no effect on intracellular Ca2+ dependent component. KDC-TS(165 ug-L'1) inhibited the contraction evoked by NA in rabbit aortic strips and this effect can't be changed by Nw-Nitro-L-Arginine (L-NNA) or Indomethacin (Indo).Finally, We can infer from the experiments' results: KDC-TS can improve the mice symptom of experimental cerebral ischemia. It has obviously protective effect on cerebral ishcemia mice which bileteraling ligation of common carotid arteries with vagus nerves. It improved mice auricula microcirculation. KDC-TS inhibited the contraction evoked by NA and CaCl2 in rabbit aortic strips, but has no effect on KC1. This vasodilative effect didn't depent on nitric oxide (NO) or prostacyclin (PGI2), while related to the blockade of the receptor operated calcium channel (ROC). |
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