The Clinical Study Of The Relationship Between Pregnant Diseases And Corticotropin-Releasing Hormone

Human pregnancy is a complex and harmonious process in which placenta is a very special and important organ. Pregnant disease causes hormone disbalance and increases fetus and neonates' morbidity and mortality . Study of the relationship between pregnant diseases and placenta! endocrine is very important for their prevention and treatment.Studies have shown that human placenta secretes massive corticotropin-releasinghormone (CRH)-a hypothalamic endocrinol hormone during partuition,which isthe major source of marternal plasma CRH. Along with pregnant progress,maternal plusma CRH increases,shotting up before parturition and falling down immediately postpartum. Someone report that maternal plusma CRH rise dramatically in some pathological pregnancies,such as IUGR,pretermlabor (PTL),PIH. Our experiment is to further study the role of CRH in human parturition and the relationship between CRH and some pregnant diseases. The experiment is composed of three parts:firstly we measure the concentration of CRH in PTL and normal pregnancy,to study the trigger role of CRH in parturition;secondly we study the variation of CRH level in different conditions during parturition;at last we mesure the level of CRH in different pregnant diseases.Results:l.The maternal plasma CRH concentration in PTL is higher than normal labor (P>0.05). After effective anti-PTL medication the maternal plasma CRH in PTL fall back significantly (P=0.023). 2. The plasma CRH concentration between uterus-abstracting group and non-uterus-abstracting group,OT-utilizing group and non-OT-utilizing group,Caesarean group and vaginal delivery group has no significant difference (P>0.05). 3. The maternal plasma CRH concentration in PTL,PIH,PROM,ICP,pregnant incorporating hepatic dysfunction and pregnant incorporating anemia is higher than normal pregnant woman (P<0.05),whereas oligohydramnios' is lower (P<0.05) and IUGR,polyhydramnios and fetal macrosomia level (P>0.05). CRH in term pregnant diseases is higher than contrast (P=0.005).Conclusion:The phenomenon that maternal plusma CRH rise in PTL and fallback significantly after effective anti-PTL medication implies:the maternal plusma CRH maybe a PTL's forcasting and curative-effect monitoring index. The maternal plusma CRH in different pathological pregnancy varies,which machanism is still to be inquired for.