The Clinical Significance Of Detecting IL-6 And IL-8 Concentrations In Serum And Bronchoalveolar Lavage Fluids From Pulmonary Tuberculosis Patients

Objective:to explore the changes of interleukin-6 and interleukin-8 in serum from pulmonary tuberculosis patients , relationship of concentrations of IL-6 and IL-8 in bronchoalveolar lavage fluid with tuberculosis activating scores which affect clinical diagnosis \ management and prognosis. Methofds: we use radioimmunoassay to measure the concentrations of IL-6 and IL-8 in serum from 24 tuberculosis patients (primary TB 1 , military TB 2 , adult TB 14 , chronic fabric cavity TB 2 , tuberculosis pleural effusion 3 , bronchial TB 2), 18 normal volunteers , in bronchoalveolar lavage fluids from 14 TB patients which produce scores according to ESR , sputum-positive , area , toxic sympton , cavity , complications and drug resistence . The scores are often regarded as the standard of tuberculosis activity . Results:we find the concentrations of IL-6(193.125 + 57.87) and IL-8(495.29+99.60) in serum from 24 tuberculosis patients are higher than those of IL-6(48.72 + 7.67) and IL-8 (164.72+45.53) in serum from 18 normal volunteers (all p<0.05). In addition , a positive correlation is found between the concentrations of IL-6(82.64+18.73) and IL-8 (3466.14+1029.02) in bronchoalveolarlavage fluids from 14 TB patients and the tuberculosis activating scores (Pearson: rIL-6=0.777, rIL-8 =0.720,p<0.01; Spearman: rIL-6 =0.796, r1L-8=0.725,p<0.01). Conclusion : our results indicates that the concentrations in serum from pulmonary TB patients are higher than those of normal adults and a positive correlation is found between the concentrations in BALF from pulmonary TB patients and their TB activating scores . Thus , with measuring the concentrations of IL-6 and IL-8 in serum and BALF, we can detect the activity of pulmonary tuberculosis patients . It indicates very importantclinical value to detect prognosis and research cytokine net of pulmonary TB.