| The research of ability for human to endure hot environments has been paid attention all through the ages. It determined whether human being could adapt to hot environments and survive themselves effectively during the course of interaction between human being and environments. By the military special environmental medicine, it was more important for soldiers to maintain effectiveness in the hot battle fields. However, as the advanced center of regulation, the central nervous system (CNS) acted an important role in the adaption of hyperthermia. So, it has an important significance to enhance the work and battle effectiveness in tropical areas, as well as to decrease the non-battle sacrifice that we study the interaction between hyperthermia and CNS, and explore the methods of increasing the adaptive abilities. Many studies showed that heat affected the CNS mainly through the afferent impulse of skin receptor and the heated blood, and then aroused a series of changes in neuroendocrine and immunological functions, as well as in the change of cerebral functions. In praxiology, it may cause the decrease of cognitive ability, the rate of response and the increase of errors. Furthermore, it may significantly affect the daily life, work and even health and life. Now, studies on the developmental malformation of CNS in abroad are reported more and more, but there are few reports about the stress response after hyperthermia in neural cells. So, it is important to study the effects of hyperthermia on CNS. However, hippocampus, as an important area about cerebral limbic lobe, has a close relationship with the cognitive ability and is an important areaabout study and memory. Hence; it is important and significant to study the effects and the mechanisms of hyperthermia on hippocampal neural cells and find the methods to decrease the impairments.The recently study have shown that the programmed cell death played critical roles in a wide varity of physiological stress progress not only in the elementary model organisms, but also in the advanced vertebrates. Apoptosis is an important mechanism in the regulating life mobilization during the evolution. In most cases, physiological cell death occurred by apoptosis is necessary to the development of the body and the theimmunological function. On the contrary side, Ultra-apoptosis is a main pathway of responding to the severe environments (including hyperthermia, hypoxia and ionization radiation). There are many hypothesizes about the mechanism of hypoxia and ischemia including excitability amino acid, monoamine neurotransmitter, disorder of Ca2+ and NO and so on. But most scholars approve it is multiple factors that caused the death of cells in CNS. The study have shown that protein kinase C (PKC), Bcl-2 and Ca2+ playing an important role in the apoptosis induced by stress. The study have shown that there is at least 12 types of PKC isoforms extensively existed in the histocyte of the body and distributed in the cell membrane and cytoplasm. The molecular essence of them was a kind of protein kinase with a single peptide chain constitution. After activation, PKC played extensive roles through activating substrate proteins which lied in the membrane and cytoplasm, and regulated the cell metabolism and physiological function. The study of PKC increasing or suppressing apoptosis all have been reported. The role of PKC in the brain injurywas still not observed.Bcl-2 is the first protooncogene which can suppress the apoptosis of cells among B-cell lymphoma. The study have shown that Bcl-2 had been expressed not only during the whole developing process of CNS, but also in the CNS of immature rats. Bcl-2 maintained at the high level during the programmed cell death in brain developing stage, and then gradually decreased with the aging. To verify the suppressing apoptosis role of Bcl-2, Mo-toyama etc cultivated Bcl-2 defected-rats using embryonic stem cell homologous recombination, the results showed that there were extensive neurons death embryo brain and spinal cor... |
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