The Significance And Relationships Between TopoⅡα,E-cd And P27 Expressions In Oral Squamous Cell Carcinoma

Objective: To study the role and c1inical significance of expressions of TopoIIQ,E-cd and P27 during the carcinogenesis and deve1opment of ora1 squamous cellcarcinomaMethods: The protein expressions of TOpo II Q,E-cd and P27 wereexamined by itnmunohistochemistry S-P method in l0 cases of oral normal mucosa,l 2 cases of inflammatory hyperplasia,14 cases of dysplasia mucosa and 5l cases ofsquamous cell carcinoma.Results: The low expression of Topo II Q was seen in allnormal mucosa and inflammatory hyperPlasia, no high expression was observed.The high expression rate of Topo II Q in displasia mucosa was 2l .4%,in squaxnouscell carcinoma was 62.7%. There was significant difference between dysplasiamucosa and squamous cell carcinoma (P<0.05). No significant correlation was seenbetween the expression of TO po II Q and clinicaI pathological factors (P>0.05) .Thepositivity rate of E-cd was 100%,83.3%, 57.l%, 49.0% in oral normalmucosa,inflammatory hyperplasia, dysplasia musosa and squamous cell carcinomarespectively. There was significant difference between ora1 normal mucosa,inflammatory hyperplasia and squamous cell carcinoma (P<0.05).The expression ofE-cd was related to the lymph node metastasis in oral squamous ce1l carcinoma(P<0.05), but not related to other clinical pathological factors. The high expressionratC of P27 was 90%,66.7%, 7l .4%, 3l .4% in oral normal mucosa,inflammatoryhyperplasia,dysplasia musosa and squamous cell carcinoma respectively. Therewere no relationships with P27 and clinical pathological factors (P>0.05).COuclusions: Our data indicate that the abnormal expressions of Topo II Q,E-cd andP27 play the main role during the caxcinogenesis of oral squamous cell carcinoma.Comprehensive analysis of TOpo II Q, E-cd and P27 will assist in evaluatingprognosis and indicating the clinical therapy.