A Study Of Risk Factors For Gestational Hepatitis B

A Study of Risk Factors for Gestational Hepatitis BObjectiveGestational Hepatitis B (GHB) is defined as a complicated disease including both first onset and first recognition during pregnancy. It was greatly harmful to the health of mothers and infants. HBV can be transmitted vertically from mothers with GHB or HBV carriers to their infants. It was associated with an increased risk of morbidity and mortality. The aims of the study is to explore the risk factors for GHB, so that we can provide evidences for prevention from and control of it.MethodsA case control study was carried out. 23 GHB cases and 100 controls were selected from hospitals in Tanggu District in Tianjin through July.2001 to Dec.2002. The questionnaire was used to obtain the information of subjects which includes demographic characteristics, history of past illness, history of present illness, psychological and social factors > obstetrics factors and some other variables. Non-conditional regression analysis was used to analyze the risk factors for univariate and multivariate. All the data processing was on the computer by program of SPSS version 10.0.Results1 The age ranges are from 21 to 32 with the average age of 26.17 + 2.94 for case group and 20 to 39 with the average age of 26.03 + 3.38 for control group.In addition, the pregnant weeks ranges are from 37 to 41 withthe average pregnant weeks of 39.17 +1.30 for case group and 37 to 42 with the average pregnant weeks of 38.96 + 1.22 for control group.2 A non-conditional logistic regression analysis show that associations of 10 variables with GHB were statistically significant, including degree of education (OR=2.591, 95%CI1.278-5.252) (The higher degree of education pregnant women were, the higher risk they were.), occupation (OR=2.581, 95%CI1.358-4.904) (The more brain labor's pregnant women took on ,the higher risk they were.), family income (OR=3.467, 95%CI 1.348-8.918) (The higher income pregnant women earned, the higher risk they were.), history of injection (OR=8.981, 95%CI 1.970-40.949), history of parental HBV (OR= 3.608 , 95%CI1.067~12.197) , meal-manners in public (OR=8.626, 95%CI 2.443-30.451) (The more pregnant women had meals with other people all together, the higher risk they were. ), washing tools (OR=7.349, 95%CI 1.152 -46.864) (The more pregnant women used washing tools in common, the higher risk they were.), history of husband's HBV (OR=20.837, 95%CI 2.206 -196.828), blood type (OR=1.561, 95%CI 1.027-2.372) (The turns from high to low were type AB, type O, type B and type A.) and complications with delivery (OR=12.179, 95%CI 3.965-37.4092).After adjusting for family income, occupation and complications with delivery, the results showed that they still increased the risk of gestational hepatitis B.The three protective factors were the han nationality (OR=0.136, 95%CI 0.021-0.868), plant-oil intake (OR=0.395, 95%CI 0.169- 0.923) and blood type A (OR=0.177, 95%CI 0.039-0.799).ConclusionA non-conditional logistic regression multivariable analysis showed: occupation -, washing tools and complications with delivery were independent risk factors for gestational hepatitis B.