| Objective :Detect the index about breathing control of the normal and OSAS patients during wake and different sleep stage; To find out the effect of sleep on respiration and the abnormal respiratory control in OSAS patients; Probe into the possible mechanism of sleep apnea. Method : OSAS patients 23 case ,control 17 case, were measured VT, MV, Respiratory frequence (R-R ),P0.1 during wake, NREM sleep (I,II),REM sleep by a oral-nasal mask connecting the Respiratory drive apparatus (GERMANY, Jaeger),In the same time PSG were doing.Result: (1) During wake P0.1 and MV in OSAS patients were remarkably higher than that of controls, there were no difference in VT and R-R phase.(2)During sleep, both the controls and OSAS patients , VT ,MV,P0.1 were lower than wake stage; In REM sleep the change was remarkable. The change of R-R uncertain. (3)The decreased change of VT ,MV,P0.1 between NREM,REM sleepand wake ,the OSAS patients were remarkable than the normals. (4)The correlation among the parameters in OSAS patients:A significant correlation of P0.1 wake with the average SaO2 in sleep :r= -0.501 A significant correlation of P0.1REM with the AHI and the longestduration of apnea :r= -0.434;r= -0.412 A significant correlation of A Po.i(wake-REM) with the AHI (r=0.597),the longest duration of apnea (r= 0.502)and the averageSaO2 in sleep(r= -0.653) A significant correlation of A Po.i(wake-NREM) with the AHI (r=0.465),the longest duration of apnea (r= 0.371)and the averageSaO2 in sleep(r= -0.585) Conclusion: 1.Sleep effect respiration function of peoples :decreased VT ,MVand P0.1, in the REM sleep the change is remarkable 2.OSAS patients P0.1 in wake is higher, the compensation of theincreased inspiratory resistance and anoxia is possiblemechanism 3.Breathing control of OSAS patients remarkably decreased duringsleep, point out the decreased of breathing control may be the possible mechanism of apnea, besides the obstruct and stricture of upper airway. |
PDF Full Text Request