Expression Of Nuclear Factor-κB In Human Colorectal Cancer And The Correlation With The Clinic Pathologic Status

Objective To explore the expression of the nuclear factor-κB in human colorectal cancer. The relationship between NF-κB and the clinic pathology status and the clinic significance was analyzed. Methods 50 human colorectal cancer patients, 9 patients of canceration of colorectal adenoma, 16 of colorectal adenoma and 8 common colon were studied, the expression of NF-κBp65 in them were examined by immunohistochemical method. Results (1)There are weak or no expression of NF-κBp65 in the common colon tissues, and in the colorectal cancer tissues, the canceration tissues of colorectaladenoma and the colorectal adenoma tissues were different. In them, the expression of NF-κBp65 in the colorectal adenoma tissues was weak male to male, and in the colorectal cancer tissues, the canceration tissues of colorectal adenoma were male to strong male. The expression in the colorectal adenoma was notable stronger than in the normal colon, in the colorectal cancer and the canceration of colorectal adenoma there are no different, but they are notable stronger than the colorectal adenoma. The expression of NF-κBp65 related the colorectal cancer and the canceration of colorectal adenoma with notable positive correlation. (2) The expression in the metastasis of colorectal cancer was notable stronger than no metastasis, and the poor-differentiation of tumor tissue was notable stronger than the good-differentiation. The expression of NF-κBp65 do not correlate with age, sex, tumor spot of colorectal cancer.Conclusion The expression of NF-κB is anomaly in the colorectal cancer, and has closelyrelation with the occurrence and metastasis of colorectal cancer. It will become a new target of treatment and one of the marker in the judging of the metastasis and differentiation of tumor tissue.