Clinical Study Of The Upper Gastrointestinal Hemorrhage

Objective: Objective to investigate the clinical characteristics in patients with upper gastrointestinal hemorrhage (UGIH) and effect of acid-inhibitory drugs on the acid-related diseases.Methods: A retrospective review of clinical recorders of 1150 patients With UGIH during 1992 - 2001.Results: (1) Of the 1150 patients, causes of 1053 cases (91.57%,1053/1150) were defined. The most common causes of UGIH in this study were duodenal ulcer(DU, 46.52%), gastric ulcer(GU, 12.00%),acute gastric mucosal lesion (AGML,8.78%), gastric cancer(GC,8.00% ), esophageal gastric varices (EGV, 5.83%) .In UGIH, male to female ratio was 3.29:1.(2) During 1997-2001,CU had a higher constituent ratio compared to 1992 ~ 1996(P=0.012),but CG showing an proportionate decrease (P<0.001).(3) Different causes of UGIH often had different degree of hemorrhage (P<0.05) . GU, DU and CU often had mild hemorrhage (P<0.05) , while the degree of AGML often was mild or moderate ( P<0.05 ) , that of GC and EGV often was moderate (P<0.05) .(4) Some UGIH often occurred in some age (P<0.001) , DU and AGML were the major causes of UGIH under the age of 40, GC was the major cause over the age of 70.(5) The detective rate of PU was higher in winter than in summer (P<0.05), and the rest detective rates had no significant difference in four seasons.(6) There were no relation between the frequency of hemorrhage and sex, age, the degree of hemorrhage, the effect of therapy(P>0.05).(7) The effect of PPI on DU was higher than that of H2RA (P<0.05 ),and there were no difference in GU,CU and AGML (P>0.05) .Conclusion: PU, AGML, GC and EGV were the most common causes of UGIH. Pathogeny distributiong was different between 1997 ~ 2001 and 1992 - 1996. There were relationship between UGIH and age , seasons , the degree of hemorrhage . The characteristics of hemorrhage should be observed. PPI is necessary for DU.