The Pathogenesis Relationship Between High Grade Prostate Intraepithelial Neoplasia And Early Invasive Prostate Carcinoma

Objective: To study the pathogenesis relationship between high grade prostate intraepithelial neoplasia and early invasive prostate carcinoma. Methods: 100 prostate specimens with representativeness were divided into 5 groups: normal prostate (NP) group, benign prostate hyperplasia (BPH) group, high grade prostatic intraepithelial neoplasia (HPIN) group, incidentally discovered prostate carcinoma (IDPC) group and prostate cancer (PC) group. Each group included 20 specimens. Using immunohistochemical staining S-P method and light microscope and electron microscope, we observed the immunohistochemical reaction and morphologic characteristics of each group and their molecular pathology changes. Results: The expression of E-cadherin (E-cad), beta 4 integrin, and glutathione S-transferase pi (GSTP1) was gradually reduced in NP, BPH, HPIN, IDPC, and PC. The expression in benign prostate hyperplasia was significantly stronger than that in high grade prostatic intraepithelial neoplasia (P＜0.01 or P＜0.05). In a part of HPIN, laminin (LN) and type â…£ collagen (C â…£) unevenly distributed around prostate acinus and duct. High molecular weight cytokeratin monoclonal antibody 34βE₁2 presented different degree and interrupted positive or strong positive stain. Low molecular weight cytokeratin monoclonal antibody 35βH11 and prostate specific antigen (PSA) could show the invasive characteristics of prostate carcinoma. We found a transition change between invasive carcinoma foci and the HPIN epithelia around them. Conclusion: The gradual inactivation of E-cad,β₄ integrin and GSTP1 In HPIN, IDPC, and PC impersonally indicates that they correlate with the occurrence and progression of prostate cancer. The expression of LN and C â…£ in HPIN can predict prostate cancer. Comprehensively analyzing results of light microscope, electron microscope, and immunohistochemical markers such as 34βE₁2, 35βH₁1, PSA, LN and C â…£ can help us to diagnosis and identify HPIN and IDPC. The morphologic relationship between HPIN and early invasive prostate carcinoma is close, and their molecular pathology changes correlating with the pathogenesis of prostate cancer is similar too.