Experimental Study Of The Prevention Of Steroid-Induced Avascular Necrosis Of The Femoral Head With Using Fugujianbu Tablet

Objective: To evaluate the preventive effect of Steroid-Induced Avascular Necrosis of the Femoral Head(SANFH) with Fugujianbu Tablet. To explore the mechanism of its roles Methods: 54 healthy adult Japanese white rabbits were randomly divided into 3 groups: Fugujianbu Tablet group, model group and blank control group. All the animals were killed in 3 batches in 4th, 8th and 12th week respectively. Then the serum Calcitonin(CT) and parathyroid hormone(PTH) were detected, the osteoblasts and osteoclasts of the femoral head were counted, and the pathological alteration in the femoral head were observed.Results: The serum PTH levels and the quantities of osteoclasts in the Fugujianbu Tablet group were significantly lower than those in the controlgroups(p<0.05),It was indicated that Fugujianbu Tablet could inhibit the secretion of PTH and decrease the quantities of the osteoclasts. The serum CT levels and the quantities of osteoblasts were significantly higher than those in the control groups(p<0.05), It was indicated that Fugujianbu Tablet could enhance the quantities of the osteoblasts and accelerate the secretion of CT. The pathologic alteration in the Fugujianbu Tablet group had no significant differences compared with the blank control group(P>0.05), It was indicated that Fugujianbu Tablet could prevent SANFH and steroid could avascular necrosis of the femoral head. Conclusions: Using steroid in high dose can lead to at last. Fugujianbu Tablet can prevent damage of bone and avascular necrosis of the femoral head. Osteoporosis may lead to the one cause of SANFH.