| Aims/Background Fresh garlic can prevent or/and therapy H.pylori infection by epidemiology survey and drug susceptibility test in vitro. So, we intend to: (1)Conduct epidemiology survey for H.pylori infection. (2)Perform health education about H.pylori and its associated disease. (3) Conduct a prospective study of preventing and curing H.pylori infection by eating fresh garlic.Methods (1)Subjects were selected by multistage sampling. The current infection rate of H.pylori and epidemic factors are survey by questionnaire and 13C-UBT. (2) According to the local epidemic factors, did health education about H.pylori by multiple forms, and then evaluated its result. (3)Undertaked a anti-H.pylori study with fresh garlic. All subjects were divided into 3 groups: group A, ate fresh garlic 10g at meal time, twice a day for one month; group B, received triple-combination therapy of metoronidazole, tetracycline and bismuth for two weeks; group C, take placebo modelling triple-combination therapy. 13C-UBT re-examined one month later. (4) Performedcost-effectiveness analysis between group A and B.Results (1) 379 subjects were enrolled in this trial, all of them have given in the questionnaires and been followed up. The total H.pylori infection rate was 55.94% by 13C-UBT . (2) After therapy, the positives of H.pylori was decreased obviously in group A and group B (P<0.001); however the positives in group C have no obvious change (P>0.05). The eradication rate of Group A and B is 66.10% and 74.51%, respectively(P>0.05), whereas that of Group C is 6.98%, which is different from Group A and B markedly (P<0.001). (3)The expense of eradicating H.pylori by eating fresh garlic is lower than that of the traditional triple therapy including bismuth agent(C/E is 0.02 and 0.80, respectively). Village residents in Yunnan is 324.63 millions, suppose the H.pylori infection rate is 50%, if all positives are treated by garlic, each course , the cost may be saved 830 millions RMB at least. (4) 9 epidemic factors were screened out by simple factor analysis. by multiple factors Logistic regression analysis, 6 important epidemic factors associate with H.pylori were screened out. (5)The H.pylori infection rate in Xiao Shiqiao and Luo He was 51.3% and 63.1%, respectively. the difference is significant(P<0.05). In Luo He, the proportion of person drinking ditch or river water, raw water and Alcohol user was higher than that of person in Xiao Shi qiao significantly(P<0.05), but the proportion of eating fresh garlic was much lower(P<0.05). (6) After health education, the understanding rate about H.pylori , H.pylori-related diseases and knowledge of protection and prevention from upper gestrointestinal diseases was statisticallysignificant compared with that of no health education.Conclusions (1) The rural area of Yuxi was a high incidence region. Poultry, livestock and water is a important intermediary in this area. Water source, habituation of drinking water, eating fresh garlic, alcohol consumption, Upper abdomen ache or malaise, etc was important epidemic factors, among them, eating fresh garlic usually was a protective factor. (2) The effect of anti-H.pylori with fresh garlic was similar to the traditional triple therapy including bismuth. But the former was the most cheap and effective strategy without side effect and drug resistance. (3)The H.pylori infection rate in Luo He was higher than in Xiao Shiqiao, which might be relation to the higher proportion of Heavy drinker, drinking ditch or river water , but littler eating garlic usually in former region. (4)Perform favorite health education about H.pylori in countryside was indispensable and effective for preventing and curing H.pylori infection, which had a profound meaning to control H.pylori infection and clinical results. |
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