Polymophism Of HIV-1 Infection Associated Genes In Dai And Jingpo Nationalities Of Yunnan

Objective: To investigate mutant frequencies and polymorphism of HIV-1resistance CCR5-â–³32, CCR2-64I ,SDF1-3'A alleles in jingpo and Dainationalities of Yunnan.Methods: The study population included 101 Dai individuals and 113 Jingpoindividuals. The genotypes were respectively detected by polymerase chainreaction (PCR) or by PCR/RFLP (restriction fragment length polymorphism)assay. Mutant frequencies were calculated and alleic polymorphism inpopulation of the three genes were analyzed by x² test.Results: we didn't find CCR5- â–³ 32. The frequency of CCR2-64I was21.0%; and the frequency of SDF1-3'A was 20.03% in Dai nationality. Thefrequency of CCR2-64I was 16.37%; and the frequency of SDF1-3'A was17.70% in Jingpo nationality. The frequencies of SDF1-3'A were both lowerthan Han nationality (P<0.05).Conclusion: Compared with Han nationality, Dai and Jingpo nationality ofYunnan might have a higher genetic susceptibility to HIV-1 (include R5 and X4strains) since we didn't find CCR5-â–³ 32 and the frequency of SDF1-3'A wasmuch lower than that of Han nationality.