Study On Pharmaceutics Of Ganzhiping Capsule

Fatty liver and acute liver-damage are common diseases and frequently-occurrin-g diseases in people's daily life. The pathological characteristics are complicated. It's difficult to cure. For a long time, people invest a large amount of fund and energy in the research and development of new drug for therapy of the disease, and many tradition Chinese medicine has unique opinions in this respect. Various of single and complex folk prescriptions have been used in treating fatty liver and acute liver-damage and gained beneficial effects, especially for the compatibility of medicine which improve the therapeutic activities and decrease the toxic effects.The Ganzhiping capsule composed of Jianghuang Chishao Haizao Fuling and compositon E has the efficiency of soothing the liver to regulate the flow of vital energy, strengthen the spleen by oozing wet firmly of invigorating blood circulation etc. It can effectively prevent and cure the fatty liver and acute liver-damage and chronic hepatitis cause to liver fibrination in clinic. The medicines in the prescription are good for curing liver complaints.In order to confirm the efficacy of the medicine, pharmacological experiments on animals were carried out and preparation technology was screened.The main com-ponents of the Ganzhiping capsule have determined, and quantitative analysis has confirmed, thus offering the scientific foundation for the preparation of the medicine.Have carried on the systematic study of pharmacy to the Ganzhiping capsule. The extraction process of Jianghuang by orthogonal design using ratio of dry extrac-tum and the curcumin content as the index: adding 10 times 90% EtOH, extracting 2 times and boiling 1.5h each time. The extraction process of Chishao and Haizao by orthogonal design using ratio of dry extractum and the C23H28O11 content as the index: adding 10 times water, extracting 3 times and boiling 1h each time. The establishment of the quality standards: Jianghuang, Chishao, Fuling and compsition E are identifyed by TLC. TLC spot is fairly clear, and the blank test showed no interfer-eance, special attribute is strong; Using curcumin as determination targest, establish the content method by HPLC. Average recovery rate was 99.05%, it is reliable to show the method accurately. Carry on preliminary stability to study to the Ganzhiping capsule, accelerated stability (40 ℃, RH75%), investigate 3 month, The Ganzhiping capsule was studied for six months under room temperature. The result showed it kept stable during the time.In the pharmacological studies, the result prove the Ganzhiping capsule can elimination fatty liver effectively and lighten the symptom of liver complaint.