Study Of The Effect And Mechanism Of Relieving Superficies And Detoxicating Therapy Treating Virus Infection Of Respiratory Tract Disease

This lesson studies relieving superficies and detoxicating therapy treating the virus infection of respiratory tract disease from theories to experiments. Expatiate the lawmaking and application principle of the therapy. Adopting the in vitro and in vivo experiments method combine together, applying the mature and stable animal model, imitate the invasion and main pathologic change of virus infection of respiratory tract disease from many links , and use technology of CLSM and FCM to analyze the mechanism of antivirus function of traditional Chinese medicine for the very first time, studying the function and mechanism of relieving superficies and detoxicating therapy treatment this kind of disease from thetwhole, cell and molecular levels. Research results show: 1 , relieving superficies and detoxicating therapy has the function of broad-spectrum antivirus. This therapy has antivirus functions of seven kinds of virus which are the main cause of virus infection of respiratory tract disease in vitro experiment, such as parainfluenza virus, respiratory syncytial virus, adenovirus3 , 7types, herpes virus 1 , II types etc. In vivo experiment, this therapy has the function of anti-influenzavirus.It has protecting function of the death of mouse which cause by the influenza virus, and it also can prolong the exist time and decrease the death rate of the mouse. The mechanism of its antivirus function is4increasing the mobility of cytomembrane which infected by virus. This can refrain the further swallow of virus. At the same time, this therapy also can regulate the immunity function of the organism, developing the antivirus functionof cellular immunity. 2 , Relieving superficies and detoxicating therapy can inhibite the virus pneumonia of mouse obviously. This therapy can reduce the pulmonaryinflammatory exudation and edema, lowering the lung index. The mechanism of anti-inflammatory function is to represses the synthesizing and releasing of inflammatory factor NO , thus can alleviate the lung damage. 3 , Relieving superficies and detoxicating therapy has the functions of febrifuge, It can decrease the high temprature which caused by the yeast fungus and endotoxins obviously. The experiment research confirms that this therapy can decrease high temprature caused not only by exogenous pyrogen, but also by endogenous pyrogen. 4, Relieving superficies and detoxicating therapy can regulate the immunity function of mouse which infect with influenza4virus. This method can raise the helper T cell , while decrease the cytotoxic T cell at the same time selectivity, making the ratio of the two goes up , thus make the organism of virus infection keep a good immunity condition.