Clinical Study On Relationship Between Transforming Growth Factor Beta1 And Diabetic Nephoropathy

Objective To investigate the clinical value of transforming growth factor beta-l(TGF-β 1) inthe diagnosis and severity assessment of diabetic nephropathy (DN) .Method Serum and urinary TGF- β 1 levels were detected with enzyme-linkedimmunosersorbent assay(ELISA) in 70 patients with type 2 diabetes and 20 controls. Urinaryretinal-binding protein(URBP) , urinary albumnin excretion rate(UAER) were also measuredsimultaneously.Result Serum and urinary TGF- P 1 levels significantly increased in diabetic patients comparedwith that in health controls ( P < 0.01, respectively), and further rose as the nephropathyprogressed. Serum and urinanry TGF- P 1 levels in diabeteic patients with albuminurinary wassignificantly higher than that of normolalbuminuric subjects (P < 0.01,respectively). Whencompaired each other, significent differents in Serum and urinary TGF- β 1 levels between in threediabetic groops(P<0.05). Serum and urinary TGF- β 1 levels were highly correlated(r=0.347, P< 0.01 and r =0.651,P < 0.01 repectively) with URBP which was higher significantly than-incontrols( P <0.01) .A postive correlation was also found betwteen Serum TGF-β 1 and urinaryAlb(r=0.402,P<0.01),urinaryTGF-β1 and urinary Alb(r=0.523,P<0.01).Conclusion TGF- β 1 might be an early marker for predicting diabetic nephropathy andassessing its severity.