The Study On Relationship Between Serum Lipid Apolipoprotein Lipoprotein And Acute Cerebralvascular Disease

Background and Purpose: The relationship between serum lipid , apolipoprotein , lipoprotein and acute cerebralvascular disease attracts increasingly attention. In all recruit patients we assessed a fasting serum total cholesterol(TC) , triglycerides (TG) , low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein(HDL) , apolipoprotein Al(ApoA1), ApoB , and lipoprotein(a) [Lp(a)]. Samples were drawn at least 24-48h from the onset. Through all kinds of mechanisms, the lipid leads to the atheromatosis in cerebralvascular, they mainly promote large vessel atheromatosis rather than small vessel arteriolosclerosis, especially vessel 500 m .It has been reported that high serum lipid could predict the occurrence of stroke. However the relationship between serum lipid and various clinical situations in stroke are not sure. We detect those lipid pofile and efficiently reduce it in order to prevent the occurrence of stroke.Methods: 1. All patients with acute stroke to our hospital were recruited, each patients was examined by CT or MRI and without live, renal, heart disease , tumor. The control subjects matched for age, sex were recruited from the healther and were excluded if they have liver , renal, heart, immunitysystem disease. 2. Serum TC, TG concentration were assayed enzymatically; the LDL-C , HDL , ApoAl , ApoB concentration were measured by turbidimetric immunoassay; Lp(a) concentration were determined by enzyme-linked immunosorbend assay. Use Olympus ALL2700 3. Statics methods by spss10.0 .Results: We find that the serum lipid is significantly increased in CI, ACH patients rather than control subjects (P<0.05) , between CI, ACH patients have no statistical difference (P>0.05). The serum lipid is significantly increased in LVD patients than the control subjects (P<0.05), in SVD patients the serum lipid is significantly increased compared with the control subjects excluding LDL-C, ApoB (P<0.05) , there are only significant increase TC, Lp(a) level between LCD, SVD (P<0.05) . No significant differences are demonstrated among Lp(a) level with different age, sex in LVD, SVD and control patients (P>0.05) . Logistc analysis show that the all serum lipids are risk factors for stroke.Conclude: We find that patients with acute stroke have higher TC, TG, LDL-C, ApoB, concentration and lower HDL, ApoAl. TC has relation to CI and ACH, TG, LDL-C, ApoB has relation to CI. Lp(a) as a independly marker for a predisposition to cerebralvascular disease , it has no relation to age, sex and is determined by genetic factor. Logistc analysis show that the all serum lipids are risk factors for stroke, it is mainly associated with LVD. The role ofserum lipid lipoprotein can not only predict the occurrence of stroke but also the stroke subtype, we can efficiently reduce the serum lipid TC, TG, ApoB, LDL-C concentration and raise the HDL, ApoAl concentration to prevent the stroke.