| IntroductionThe occupation exposure which arises from ionizing irradiation in medicine is in low level and durative. It was suggested that the occupation exposure population have a higher risk in malignancy such as leukaemia and dermal cancer by epidemiological studies. While intervention radiology has developed rapidly, occupation exposure has increased without effective radiation protection measures due to the particularity of operations. It was reported that injuries to intervention radiologist occurred in excessive dosage exposure overseas, but the domestic research has not given enough attention to the occupational health effect. With the aid of the cytogenesis method, observations of cell genetic toxic effects in occupation population may reflect the risk of stochastic effect from radiation as well as the individual radiosensitivity. So, it is important to investigate the latent or existent biological effect of the occupation exposure and the relations among them regarding the protection occupation crowd health, radiation protection measure established, latent radiation danger controlling, ionization radiation practice promotion in medicine.MethodUsing real -time simulated survey on the scene and thermoluminescent do-simeters (TLD) measuring technique, occupation exposure level was investigated. Micronucleus (MN) assay in peripheral lymphocyte was used to appraise cell genetic toxic effect from ionizing radiation. 189 radiation workers from large - scale hospitals in Liaoning Province was cluster sampled to study the relation between occupation exposure dose and cytogenetie index by multi - varianceslinear regression.ResultReal - time simulated survey on the scene is close to TLD dose meter measuring result. Dosage in several positions was calculated and modified to unitary. It showed that hands received the most dosage than other organs. The dosage of intervention radiologists was nearly ten times higher than the other radiologists. The complexity of exposure dosage in intervention radiologists can be shown in two aspects: (1) the difference of individual dosage varies in different places, operative methods, equipments and the types of work; (2)the dosage of different organs and parts of body (e. g. lens, hands, lower limbs) varies individual-iy- ' .White blood cell counting and eye lens checking did not indicate significant difference between intervention radiologists and other radiologists, but MN assay did, although no significant dose - effect relation was shown. Dosage and MN frequency comparison between male and female indicated MN assay was more sensitive in female. Multi - variance linear regression showed MN frequency was related to age.DiscussionIn this study, the exposure dosage of intervention radiologist was significantly higher than other radiologist, but it is generally lower than other studies in China. The reason was that the sample objects in this study were picked from large - scale hospital in which more effective measure was carried out for radiation protection. In fact, the radiation exposure on intervention radiologists was more serious, measure should be taken to control and decrease exposure dosage. In this study, MN frequencies in intervention radiologists was significantly higher than non - intervention radiologists. However, the relation between exposure level and MN frequency was not well defined. It may be caused by greater disturbance of many confused factors in lower dosage level. According to the resultsof statistical analysis, the response to MN assay is more sensitive in female than in male. With the increase of age, the MN frequency tends to increase. It is advisable to evaluate the harm caused by radiation with MN assay. And this index can also be used to reflect the individual radiosensitivity and the combined effect of other factors. Further study is needed to evaluate the effects of other factors.Inclusion1. Occupational exposu... |
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