The Clinical And Experimental Study Of Pinellia Tuber Against Emesis And Tumor

Chemotherapy and radiotherapy are associated with emesis as a common adverse reaction in the treatment of malignant tumor, the rate of emesis induced by cytotoxic drugs was very high. At present ,the commonly used antiemetic drugs are 5-HT3 receptor antagonist(such as ondansetron) and dopamine antigonist(such as metoclopramide), these drugs have have many side effects. In order to carry on the Chinese traditional medicine , having the aid of the new vomiting model in Minks, we study the actions of pinella tuber. The follows are the results:1 Ethanol extraction and water-decoction of pinellia tuber (processed with ginger inhibited the emesis induced by cisplatin (7.5mg-kg-1,ip),the number of emesis are 54.5; 63.5; 8.0 and 10.0 (p<0.01).2 Ethanol extraction of pinella tuber (processed with ginger) inhibited the emesis induced by apomorphine(1.6mg-kg-1,sc), the latency of vomit is prolonded, the number of retching and emesis are 10.3 and 2.3(p<0.05).3 Raw pinella can induce emesis in minks, the number of retching and emesis are 78.3 and 13.3.4 In the clinical experiment of Chemotherapy of tumor, The total effective rate was 91.4% in the pinellia tuber combination with ondansetron group and was 80.8% in contrast group(P<0.01).5 In the clinical experiment of radiotherapy of tumor, The total effective rate was 78.6% in the pinellia tuber and was 76% in mono-radiotherapy group(p>0.05).6 Inhibitory of pinellia tuber(10, 5, lg-ml-1)against implanted S180,H22 and EAC tumors in mice were 57.5, 32.9, 26%; 24.7, 30.9, 35.1% and 12.8, 20.5, 30.1% respectly compared with that in control groups .Inhibitory of pinellia processed with ginger (10, 5, 1g-ml-1) against implanted S180,H22 and EAC tumors in mice were 63.1, 47.4, 57.7%; 36.3, 32.4, 38.4% and 20.5, 28.9, 27.2%.7 In cisplatin group,the assay of distribution of 5-HT3 was performed by immunohitologic method,The result showed that 5-HT3 receptors stimulate abdominal vagal afferent neuros which may be an important mechanism involved in vomiting.The results suggested that pinellia tuber have many actions such as antiemetic and anti-neoplasia, studying the active chemical constituents and its mechanisms in pinellia tuber may be great value in screening new antiemetic and anti-neoplasia drugs.