Symptom Features And Pathogenisis Of Decompensated Liver Cirrhosis With Ascites And Intestinal Endotoximia And Treatment By TCM

1 ObjectivesTo observe the symptoms and signs of patients with decompensated liver cirrhosis combined with intestinal endotoximia. To study the curative effects of compound formula qing-du-tang .To search for a effective way to treat intestinal endotoximia for the patients with decompensated liver cirrhosis combined with ascites.2 Methods2.1 CasesAll the cases are hospitalized patients in Ditan Hospital, from January, 2002 to January ,2003;aged from 18 to 65. All the patients meet the the diagnosis of decompensated liver cirrhosis, combined with ascites and intestinal endotoximia.2.2 Therapetic regimen60 cases were divided into 2 groups according to the admission time, one for therapy group, another for contrast group. The basic treatment is similar to the two groups: thymic peptide injection 100mg/d; Xiang-Dan Injection 40ml/d. Dihydrochlorothiazide 25-50 mg/d ; Aldactone 20-100mg/d. Antibiotics was given according to the case condition. Qing-Du-Tang decoct was used in the therapy group for 10 days, 100ml, twice a day. Lactulose was used in the contrast group for 10 days, 10-20ml, twice a day.2.3 Observations2.3.1 Observed the symptoms and signs of patients. Score the main symptoms and signs . 2.3. 2 Compared the changes of total scores for the main symptoms between the therapy group and the contrast group. Compare the changes of the liver function , renal function, and endotoxin quantitation of the two groups.3 ResultsFever, severe abdominal distention, abdominal pain, nausea, vomit, dark red tongue, thick and greasy tongue fur, dry stool were observed in the patients with intestinal endotoximia . It showed the features of wet heat , qi-stagnancy and blood stasis. Qind-Du-Tang was better than Lactulose on improving symptoms, eliminating endotoxin and lowering blood ammonia.4 ConclusionThe patients with liver cirrhosis combined with ascites and intestinal endo -toximia showed asthenia in origin and sthenia in superficial it. Asthenia inorigin was marked by hepatic and renal yin deficiency, asdthenic splenonephro-yang; sthenia in superficial it included wet heat, toxin, stagnant blood. Disfunction of liver, spleen , kidney and wet heat , toxin , stagnant blood coalescing together were its main pathogenisis mechanism . Qing-Du-Tang had the effects of clearing heat, depriving the evil wetness, promoting blood flow, detoxicating, opening bowels, nourishing yin and cooling blood. It showed better effects on clearing endotoxin in this study. No side effects were observed.