Expression Of Thymidine Phosphorylase And Vascular Endothelial Growth Factor In Invasive Breast Carcinoma And Their Relation To Tumor Angiogenesis

〖OBJECTIVE〗 1,To detect the expression of thymidine phosphorylase ,Vascular Endothelial Growth Factor and Flt—1(VEGF`s receptor)in the advanced breast carcinoma and the relationship between their expression and the clinical stages ,pathological grades and lymph node metastasis.To analyze the relationship between the expression of TP and prognosis of the patients with lymph node metastasis in order to evaluate whether the expression of TP could be as a chemotherapeutic efficacy index in those patients mainly treated with 5—FU.To study the role of TP in the tumor angiogenesis of breast carcinoma and the way of VEGF in promoting the tumor angiogenesis.〖METHODS〗 The expression of TP ,VEGF,Flt-1 in 102 cases with advanced breast carcinoma and 24 cases with benign breast lesion was immunohistochemically assessed.Intratumoral microvessel density (MVD) was detected with anti—CD34 monoclonal antibody .The difference of their expression between in benign tissue and in malignant lesion and the relationship among the expression of themselves were analyzed.〖RESULTS〗 The expression of TP ,VEGF,Flt-1 and MVD in malignant tissue are higher than that in benign tissue .The group with higher expression of TP has more possibility to appear lymph node metastasis .There is a positive association between the level of tumor TP expression and clinical stages ,pathological grades and prognosis of the patients with lymph node metastasis and Fu—based chemotherapy ,as well as the expression of VEGF and Flt-1.〖CONCLUSION〗1,The expression of TP can be as a Fu—based chemotherapeutic efficacy index in patients of invasive breast carcinoma with lymph node metastasis.TP can accelerate the tumor`s growth and inhibit it`s apoptosis;TP and VEGF interact and co-promote the tumor angiogenesis,then lead to infiltration ,metastasis and the progression of breast carcinoma.VEGF bind it`s receptor by the way of paracrine or selfcrine and promote the tumor angiogenesis;MVD can be an isolate factor to predict the prognosis of the patient with invasive breast carcinoma.