| Objective(1) Observing the prevalence of post-stroke depression (PSD) to find out whether or not early anti-depression treatment by fluoxetine can either intervene PSD or be any beneficial to the rehabilitation after stroke.(2) Researching the relationship between blood 5-HT concentration and PSD to find out the influence of fluoxetine on plasma and platelet 5-HT concentration.Methods66 patients who were stroke (2003.09-2004.02) were chosen and divided into fluoxetine treatment group and regular treatment group. The regular treatment group only received regular treatment, while the fluoxetine treatment group received four-week fluoxetine treatment after one week regular treatment. Patients were evaluated by HAMD, ADL and SSS at the 1st week and the 5th week after stroke. Meanwhile, plasma and platelet 5-HT concentrations were measured by high performance liquid chromatography fluorescence detector.ResultsThe prevalence of PSD after stroke is 38.24%. The fluoxetine treatment group is scored lower than regular treatment group in the HAMD scale after treatment (P<0.05). Although rehabilitation evaluated by SSS and ADL is found in both groups after 4-week treatment (P<0.05 ) , advantages of fluoxetine treatment can be observed (P<0.05 ) .Generally, the platelet 5-HT concentration of PSD patients is normal, fluoxetine reduced platelet 5-HT concentration after 4-week treatment (P<0.05 ) . No notable difference in platelet 5-HT value can be observed before and after regular treatment (P>0.05) . No notable change in plasma 5-HT concentration can be observed in both groups before and after treatment (P>0.05) . ConclusionPrevalence of PSD is often after acute stroke. Early treatment by fluoxetine can release the symptom of PSD and promote rehabilitation of PSD patients. The effect of plasma 5HT value is not clear. The platelet 5-HT concentration of PSD patients is normal; however, fluoxetine treatment can reduce the platelet 5-HT concentration of stroke patients. |
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