The Clinical Research Of Multi-cluster Radiofrequency Ablation Combined With Portal Vein Chemotherapy In Hepatocellular Carcinoma

[Objective] To investigate the therapeutic effects of multi-cluster radiofrequency ablation (RFA) and portal vein chemotherapy (PVC) in hepatocellular carcinoma (HCC), study the immunity alternations in the patients. [Materials and Methods]1. 54 HCC patients were divided into two groups randomly. RFA was undertaken in 31 patients with RF-2000, RF-3000 radiofrequency generator. In the combined group, 23 patients received RFA therapy combined with percutaneous PVC under ultrasound, and repeated PVC after ten days, one month, two months, three months, six months. The hepatic and renal function, AFP level of the two groups were recorded before and after therapy. The patients were examined by ultrasound or CT one month later and were followed up regularly. Then tumor remission and one-year survival rate were accounted. 2. TNF-a , s!L~2R level were compared in 26 cases before therapy and after ten days by chemiluninescent immunoassy technology. Ten healthy adults were selected as control group. Their TNF- a , sIL-2R concentration were measured by the same technology. [Results] 1. Slight hepatic dysfunctions in both groups were observed after one week and recovered one month later. The AFP level decreased (j°CO. 05). Ultrasound and CT showed up that the tumor tissue became necrotic significantly after therapy. In RFA group, complete and partial remission of HCC accounted for 67, 7%(2l/31), one-year survival rates were 83. 9%(26/31).In united group, complete and partial remission of large tumor(Φ >5cm) reached 92.9%(13/14), one-year survival rates were 91.3%(21/23). No serious complications were encountered except for one case of skin cauma, one case of biliary tract hemorrhage. 2. The serum sIL-2R and TNF-a level in HCC patients was higher than that of healthy control group, and drop after RFA therapy (P<. 05) . The tumor diameter was positive corretation with sIL-2R(r=G. 9238, /KO. 01). [Conclusions] 1. RFA combined with PVC under ultrasound is an effective, safe treatment for HCC patients. RFA can improve the patients' immunity. 2. The efficacy of RFA combined with PVC is better than that of RFA in large tumor(φ>5cm) of HCC. This combined therapy can prolong survival time of the patients.