Study On Immunopathology Of Host Due To Different Types Of Infection Of Schistosoma Japonicum

Two different modes of single-infection and repeated-infection of Schistosoma japonicum have been established. The damages of hosts' immunopathology and the fibrosis in the liver were estimated through testing Hyaluronic acid (HA) and Laminin (LN) and IgG in sera and TGF-PimRNA in livers .The purposes are to study the effects on liver fibrosis of the same number of cercaria through single-infection and repeated-infection in acute phase and chronic phase and advanced phase. The results show that the biggest size of egg granuloma can been seen in the acute stage and then become smaller and smaller in the later in single-infected animals , but there are no significant changes in repeated-infected animals. The amount of HA and LN in sera are above the normal in all infected animals. The average number can drop to normal in single-infected animals through treated with praziquantel, but cannot do in repeated-infected animals. The antibody of IgG in sera can be detected in the sixth week after infection and become more and more and it has a trend of decline from the eighteenth week. The amount of TGF?RNA in livers are higher than normal in each group ,but more significant in repeated infected group. The results show that it is predominant of egg granuloma in acute stage but fibrosis in chronic and later stage; and the repeated infection can cause greater damage in host than that of single infection with the same number of cercaria .