The Effect Of Partial Liquid Ventilation In Rabbits With Pulmonary Edema After Seawater Drowning

The concept of pulmonary edema after seawater drowning (PE-SWD) is the liquid accumulating excessively in lung tissue because of the seawater drowning, which lead to the increase in weight and volume of the lung, and hypoxemia is the primarily clinical performance of PE-SWD. If not treated effectively on time, it would convert to respiratory distress (SW-RDS) soon which is critical and liable to death.Partial liquid ventilation (PLV) is a new treatment beginning from 1990s. The previous experiments indicated that PLV can significantly improve the gas exchange and pulmonary compliance of animal with acute lung injury(ALl). The aim of current study is to evaluate the effect, pathophysiologic and histopathologic changes of PLV in treatment of PE-SWD.Part I The effect of partial liquid ventilation in rabbits with pulmonary edema after seawater drowningObjective To observe the effect of partial liquid ventilation (PLV) on gasexchange, pulmonary compliance, blood dynamics in the pulmonary edema rabbits after seawater drowning, methods 42 healthy male new Zealand rabbits were randomly allocated to three groups (n=14). Every group was treated with various methods after PE-SWD model established. They are as follows: PE group with no treatment, CMV group with conventional mechanical ventilation and PEEP, PLV group with CMV, PEEP and FDC. All rabbits were treated for 3 hours. Blood gases, pulmonary mechanics, hemodynamics, pulmonary histopathology and alive time were observed during the experiment. Results In PLV group, PaO2 increased obviously, airway pressure decreased, pulmonary dynamic compliance increased and pulmonary injury reduced. HR and MAP showed no significant changes after treatment compared with PE group. But alive time had no difference with PE group. Conclusion Pulmonary gas exchange and compliance improved significantly during PLV in the PE-SWD rabbits without obvious influence on hemodynamic status. Although alive time of PLV group is less than CMV group.