A Study On The Change Of The ProANP In Patients With Acute Myocardial Infarction

Object:We intend to find out the feature and regularity of the change of pro-atrial natriuretic peptide (proANP) in patients with acute myocardial infarction (AMI) via the study of the proANPs in such patients, and to provide a novel clinic method to diagnose AMI, and if so, to make proANP ready to be a noninvasive method for the evaluation of the benefit of PCI. Method:30 patients with AMI (15 males and females respectively) were involved under random and controlled method. Samples were obtained on admission (mean 4.5 hours from the onset) (B) and on the seventh (C) and thirtieth day (D) after the PCI respectively, and normal control group (A) (10 males and females respectively) was set up. ProANP1-30 (long lasting natriuretic simulating factor), proANP31-67 (vascular relaxation factor) and proANP79-98 (potassuretic peptide) were tested with fluorescence immunoassay, and echocardiograph was performed to determine left ventricular end-diastolic volume (LVEDV) and left ventricular ejection fraction (LVEF). One way ANOVA was used to detect any significant difference among the different groups (combining Scheffe's test used for post hoc multiple comparison between groups) to discuss and reveal the feature and regularity of the change of proANP and the severity of AMI, and accordingly to figure out the regularity of the change of proANP after the process of PCI in patients with AMI. Results:obvious increase in all of proANP (1~30X proANP (31~67) and proANP (79—98) was observed in AMI patients (mean 4.5 hours from the onset) (proANPl ~ 30 与 proANP79~98 p<0.001, proANP31 ~67 p<0.05), among which there were no significant...