Obesity is an disbalance nutrition disease caused by special biochemistry factors, which lead to a series of disorders of energy, calory absorbed in body is much more than that of consumed, then stored in body fat, the final result is overweight. In our country, along with raise of living standard, incidence of a obesity uninterrupted increasing, in addition to affect body of beautiful outlook, correlated diabetes , cardia and cerebrovascular disease, certain tumor.In research on obesity, the information come from lipocyte and its biology function appear very important, discover of leptin is a break through for therapy of obesity . leptin is a kind of proteohormone coded by obese gene, excreted by lipocyte, its quantity of excretion direct ratio to adipose tissue. Feeding back central nervous system (hypothalamus) and peripheral tissue (internal organs fat, pancreas, sexual gland etc; achieve to regulate ingestion and energy expenditure, then weight step down.More researches indicate that fat people suffer mostly from leptin resistance,that's although the blood leptin level is higher than normal,the process of signal transmission exist defect, result in disorder regulation of appetite, energy expenditure and body weight.At the same time,leptin resistance destroy the normal feedback mechanism between fat-Insulin, result in insulinemia the final disease such as 2-DM, hyperlipoidemia and CAD etc. leptin resistance also affect body substance metabolism through this mechanism, result in obesity and other diseases .therefore during obesity treatment .intervention IR and improve leptin signal certainly became the break through obesity treatment.acupuncture is a kind of natural therapy, which is preponderant in transmitting messages and has well regulative function on endocrine metabolism testified in many clinical and experimental studies .acupuncture for the channels and doubtless curative effect, in which the special action mechanism of the channels and collaterals or acu-points intervening which aspect of leptin resistance is worth of deeply investigating.Traditional Chinese medicine(TCM) consider that the cause of obesity is together with the spleen and stomach, foundation on stomach-strong and spleen-week. At the beginningof obesity or youngsters fat ,mostly belong to stomach intestine sthenic fever of type, splenic asthenia run through the whole process of obesity. After animal experiments and clinical research on appetite controlling, febrific stimulating, restraining adipose composition, well regulating to weight and so on, it concluded that the effect of stimulating Stomach Channel have close relationgship with leptin.Under the long-term clinical observation and prophase animal experiment, we clinical observation 50 fat patients belonging to stomach intestine sthenic fever of type , one group treated with mostly Stomach Channel points such as two-side Liangmen, Slippery Flesh Gate, Tianshiu Wailing, Daju, Shuidao, Liangqiu, zushanli, Shangjuxu, Xiajux, Neiting etc,every time take 6-10 acupoints ,in addition to Zhongwan, Daimai and so on. The control group take two-side Weis, Zhongwan, Dachangsu and so on , In addition to Daimai, Fenglong. one time treatment alternate day ,one month course of treatment, after every course of treatment, measure weights waistline and so on, then after three course of treatment,Observe overall curative effect.The result of our clinical observation:Two groups also achieved certain curative effect, The stomach meridian group total effective rate is 88.00%, the control group reach to 68.05%, two groups has statistics deviation (p<0.05) .1. Acupuncture Stomach meridian can reduce weight, minificate waistline ,cut down BMI, at the same time depress .appetite, augment satisfied feeling, unobstructed defecation, amendment bromopnea, menorrhalgia, acne and so on. its total effective rate has significant deviation compared to control group, it illustrate that Stomach meridian points have favourable action to fat of stomach intestine sthenic fever , it also have significant action in reducing waistline than the control group.2. The level of blood leptin is a fine index of obesity-measure and weight reduction-evaluation. It obviously drop after Acupuncture Stomach meridian than the control group.3. The activity of blood ACHE is a index reflecting function of parasympathetic nervous, before therapy, the blood of ACHE is higher than normal level, it illustrate that obesity patient suffer the hyper disfunction of parasympathetic nervous. After acupuncture treatment, The activity of blood ACHE of two grop patients all became weaken than before P<0.05,but remain higher than normal . it illustrate that acupuncture can reverse the unbalance state of parasympathetic nervous in obesity.4. The correlate analyze among blood leptin, weights waistline> BMI make clear that two of these indexes all assume positive correlation (10> P<0.05) , leptin extremely correlate to waistline, secondary BMI, last weight. |