The Prognostic Significance Of The Expression Of Cytokeratin And P～(53) In Endometrial Cancer

Objective To study the roles of cytokeratin (CK) in diagnosing lymph node micrometastasis and the significance of P~53 expression in endometrial cancer and to study the relationship between their expression and clinicopathlogical features and the relationship between CK and P~53 and their impact on recurrence.Methods The expressions of CK and P~53 in 50 primary tumors and the expressions of CK in 236 pelvic lymph nodes from 50 patients with endometrial cancers were analysed by immunohistechemical methods.Results The positive expression rates of CK and P~53 in primary focus of endometrial cancer were 100% and 48% respectively. No CK expression were found in normal lymph nodes . The positive expression rates of CK in lymph nodes of stage I and stage IIIc were 8.78%,26.4% respectively(P<0.05). The expression of CK in lymph nodes was related to low histological grade and was not related to muscle invasion. The recurrence rate of patients with stage I was higher in patients with CK positive lymph nodes than CK negative ones (P<0.05). The expression of P53 in primary tumor was not related to histological grade and muscle invasion. In patients of stage I, the expression of P53 was not rated to CK expression in lymph nodes (P>0.05). There was no significant difference between stage I and stage IIIc in the expression rate of P53(P>0.05).In patients of stage I, P53 positive was not related to the recurrence (P >0.05). Multiple regression analysis revealed that muscle invasion, post-operated therapy and P53 expression were not significantly related to the recurrence of patients with stage I, the CK expression in lymph nodes and low histological grade was related to tumor recurrence in stage I endometrial cancer and the CK expression in lymph nodes was an independent factor for recurrence.Conclusion The expression of CK in pelvic lymph node without clinical metastasis indicates presence of micrometastasis. As for patients of stage I, CK expression in pelvic lymph nodes is an independent predictive factor for tumor recurrence; P53 expression in primary tumor was not related to recurrence of...