A Study Of Correlation Between Spontaneous Intracerebral Hemorrhage And B-type Brain Natriuriritic Peptide Level

[Objective] Now study shows that B-type brain natriuriritic Peptide (BNP) level in plasma increases after subarachnoid hemorrhage, B-type brain natriuriritic Peptide (BNP) level in plasma decreases after acute craniocerebral injury. To investigate the relationship between spontaneous intracerebral hemorrhage(SIH) and B-type brain natriuriritic Peptide (BNP) level in plasma, and evaluate the pertinence BNP level level in plasma and hemorrhage timing, volume, position, GCS score.[ Methods J 30 patients with spontaneous intracerebral hemorrhage were studied.30 healthy volunteers participated in the study.Age, sex and height did not differ significantly between the two group(P > 0.05). The BNP levels in plasma general condition, hemorrhage position, volume, and GCS score were measured in 30 SIH patients in 1 week after hemorrhage and 30healthy volunteers(control group) respectively. 12 SIH patients, who were admitted in 24 hours after hemorrhage, were measured twice(in 24 hours and 1week after hemorrhage).[ Results 1 The BNP level in plasma in SIH group was significantly lower than in control group (P < 0.01) , and the BNP level in plasma in 24 hours after hemorrhage was significant lower than in 1 week(P< 0.01), but the GCS score didn't change significantly(P> 0.05).The BNP level in plasma in large hemorrhage, basal ganglia hemorrhage, thalamus hemorrhage or GCS score ≤8 group were significantly lower than in middle hemorrhage and small hemorrhage, lobar hemorrhage or GCS score>8 group (P<0.05, P<0.01) .[Conclusion] The BNP level in plasma in patient with SIH significantly decreases and changes with hemorrhage timing, volume, position and GCS score, it is suggested that the concentrations of ADH and Ang II increase and there inhibit the release of BNP feedback in the patients with SIH.