Empirical Study Of The Hepatotoxicity And Nephrotoxicity Of Kwangfangchi

In the recent years, many people pay close attention to the toxic reaction induced by Chinese herbal medicine, the typical one is study about the nephrotoxicity of Aristolochic Acid (AA). AA may lead to injury of renal cells' DNA, renal interstitial fibrosis and tumour., these may bring about nonreversible renal injury to the patient. The main Chinese herbs that induce aristolochic acid nephropathy (AAN) are the plants of Aristolochia Aristolochiaceae. In Vanherweghem' s report, Kwangfangchi is the ringleader that induce renal injury. Kwangfangchi is the root of Kwangfangchi Y. C. Wu ex L. D. Chou et S. M. Hwang. The main chemical composition in Kwangfangchi is AA. The clinical report about the nephrotoxicity of Kwangfangchi is seldom, and the animal experimental data about it is scarce.Experiment studiedKwangfangchi used in this subject was buyed from Hecheng Gaoyao Guangdong. Professor Hu shi-lin accredited that it was the root of Aristolochia fangchi Y. C. Wu ex L. D. Chou et S. M. Hwang. Its content of AA was 0. 04mg/g by HPLC, and its LD₅₀ for mouse was 259. 4 ± 19. 55g/kg, the 95% average confidence level of LD₅₀ was 240. 6—279. 7g/kg. 1. Experiment about nephrotoxicityObjective To get the message about the tox-feature of Kwangfangchi' s...