The Effects Of Plasma Adrenomedullin, AT-Ⅰand AT-Ⅱ On Insulin Resistance In Patiens With Essential Hypertension

Objective: To observe the relationship between adrenomedullin (ADM) , Angiotension (AT-Ⅰ, AT-Ⅱ) and insulin resistance (IR) in patients with essential hypertension (EH) .Method: 40 patientswith essential hypertension were enrolled at random as study group which were divided into 3 subgroups according to their blood pressure levels.The concentrations of plasma ADM, AT-Ⅰ and AT- Ⅱ were determined by radioimmunoassay.And serum glucose , serum insulin and insulin sensitive index (ISI) were detected.Result: ①There was statistically significant difference between ISI and ADM , AT-Ⅱ in groups (P<0.05) .②Plasma ADM levels were negatively correlated with ISI (r= -0.713, P<0.01) . ③Plasma AT-Ⅱ levels were negatively correlated to ISI (r=-0.622, P<0.01) . ④There was no statistic difference in plasma AT-Ⅰ levels in groups(p>0.05),and there was no statistically relationship between plasma AT-Ⅰ levels and ISI(r=-0.254,p=0.31).⑤Partial correlation indicated that without the effect of blood pressure,plasma ADM levels were negatively correlated with ISI (r= -0.623, P<0.01) and plasma AT-Ⅱ levels were also negatively correlated to ISI (r= — 0.529, P<0.05) .Conclusion: There was statistically significant difference between ISI and ADM , AT- Ⅱ in groups. Plasma ADM, AT- Ⅱ levels were negatively correlated with ISI. Increased ADM and AT- Ⅱ may played an important role during the progression of insulin resistance and essential hypertension. ADM might be involved in the protective mechanism against further increase of insulin resistance.