Role Of Alcohol In Hepatic Injuries In Patients With Chronic Hepatitis B

Objective To investigate roles of alcohol in hepatic injuries in patients with chronic hepatitis B. Methods 61 patients were screened from the data bank, and divided into 5 groups of ordinary drink, spirituous liquor addict, simple chronic hepatitis B, chronic hepatitis B accompanied with ordinary drink and chronic hepatitis B accompanied with spirituous liquor addict, in which enrolled 13, 7, 15, 15 and 11 cases, respectively. The laboratory examinations as well as clinical features were collected and analyzed statistically. Histopathological changes of inflammation, fibrosis and fatty deposition in sections of liver biopsy from the patients were also analyzed retrospectively. Results No difference in symptomless rate, or serum TB, or serum AKP was found among the indicated groups, while serum ALT and AST in the group of chronic hepatitis B accompanied with spirituous liquor addict were much higher than those in the group of hepatitis B accompanied with ordinary drink, and had a higher rate of positive findings under ultrasound scan. Liver biopsy assessment showed inflammation index and fibrosis index were significantly increased in patients with chronic hepatitis B accompanied with spirituous liquor addict. Fatty deposition in both of patients with spirituous liquor addict and with chronic hepatitis B accompanied with spirituous liquor addict were much more sever than those in patients with simple chronic hepatitis B. Conclusion Alcohol may cause hepatocellular damage to a certain extent in a dose dependent manner, and alcohol had additional effects on deterioration of chronic hepatitis B associated liver damage. Furthermore, alcohol may play a key role in liver fatty deposition in patients with chronic hepatitis B.