| It is a usual practice to execute surgical treatments to vascular diseases, which need much more vessels than the acquirable natural ones. The aim of this study was to develop a biocompatible and mechanically stable vascular graft combining canine thoracic aorta vascular smooth muscle cells (VSMC) and endothelial cells (EC) and a xenogenic acellular matrix by means of tissue-engineering techniques. Furthermore, we investigated the morphology, biomechanics and the function of vascular cells of the tissue engineered blood vessels (TEBV). The structure of the reconstructed TEBV was similar to the physiological ones. The biomechanics of the reconstructed blood vessels were similar to the normal physiological ones. Cells implanted into the TEBV scaffolds have better functions, which participated in the remodeling of TEBV. |
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