A Study On The Action Of Tripterygium Glycosides (TG) Inducing Apoptosis Of Synoviocytes Of Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic systematic autoimmunedisease mainly involved in joints. Persistence of severe synovitismay result eventually in destruction of cartilage and bone of thejoint leading to permanent disability. One of the most importantpathological characteristics of Rheumatoid arthritis is theremarkable thickening of synovial lining layer, which may consistof up to 10 layers of cells instead of the 1-3 layers seen in normalsynovium, but what is the ultimate cause of the proliferation ofsynoviocytes remains unknown. Recent studies, however, indicatethat apoptosis plays an important role in regulating process ofapoptosis in RA. Some researches proved that the failure toundergo apoptosis was involved in the pathogenesis of proliferationof synoviocytes and the thickening of synovial lining layers. Atpresent, there are no enough effective therapeutic drugs yet.Tripterygium Glycosides (T G) is a Chinese traditional herbusing in treatment of rheumatic diseases since ancient time. It haswell effect against inflammation and has capability of inhibitionautoimmune by inducing synoviocytes apoptosis with Aidingdown-regulatating bcl-2 gene expression and so on, meanwhile, anexpresses abundant bcl-2 in rheumatoid arthritis synoviocytes, butit is also pity that Tripterygium Glycosides have obvious toxiceffects and yet it is obscure in the therapeutic mechanisms.In order to study whether Tripterygium Glycosides can...