Alterations Of The Levels Of Oxidative Stress Index, Vitamin A And Reproductive Hormones In The Male Workers Exposed To Dioxins And PCP (Na-PCP) And Effects Of Dioxins On The Epidermal Cells Proliferation

Objective: Pentachlorophenol(PCP) is widely used for the preservation of wood and Pentachlorophenol natrium (Na-PCP) is for the prevention of schistosome, either of which is toxic, besides a kind of dioxins will come up as the inevitable impurities with more toxic during their production. So those workers who had been engaged in the production of the PCP (Na-PCP) are easy to suffer from some short or long health effects as a result of their past exposure to these toxicants. Our present studies will determine if the workers have been influenced in the following three aspects including oxidative stress, Vitamin A homeostasis and reproductive hormones balance to provide further evidences and clues for the prevention and treatment.Methods: In this study the exposed group was defined as those workers who are engaged in the productions of PCP(Na-PCP) and the control group was defined as the unexposed comparison population. A series of assays are conducted in the plasma to obtain three main categories of index: Oxidative stress which was reflected in MDA and SOD and GSH-Px; Vitamin A homeostasis which included Vitamin A and retinol binding protein; Reproductive hormones balance which included testosterone and Luteinzing Hormone and Follicle Stimulating Hormone. Results: First, alteration of oxidative stress index: contrast with that of the control group, the levels of the MDA in the plasma in the exposed group are showed to markedly increase (P < 0.01), which suggested lipid peroxidation had taken place; the levels of SOD and GSH-Px in the exposed group had tended to decrease but the former without statistical significance (P>0.05). Second, alteration of Vitamin A homeostasis: Contrast with that of the control group, the levels of Vitamin A in the plasma in the exposed group are showed to alter without significance (P>0.05), while the retinol-binding protein had exhibited to increase with markedly significance. Third disorders of reproductive hormones balance: contrast with that of the control group, the levels of testosterone the plasma in the exposed group are...