| Objectives: To observe the effects of LiXin I on the myocardial tissue cells apoptosis of the CHF rats model with Adriamycin. To explore the function mechanism of in the treatment of HF in order to provid theoretical basis for clinical application of drugs.Methods: We apply Adriamycin to build CHF model and divide randomly Eighty-four male wistar rats into six groups: normal control group, model group, enalapril control group, XinBao control group, high-dose LiXin I group, low-dose LiXin I group. Gene-Bax , Gene-Bcl2 which regulate the rats myocardial cells apoptosis are measured through immuno- histochemical method .Results: Gene-Bax expression in the model group rats' myocardia increases obviously in contrast to the normal control group (p<0.01). Every treatment group can inhabit the CHF rats Gene-Bax expression and it is obviously different in contrast to the model group (p<0.05 or p<0.01).Among those groups high-dose LiXin I group and enalapril control group are superior to the other groups , but it is not obviously different between them. Moreover, Gene-Bcl2 expression in the model group rats' myocardia decreases obviously in contrast to the normal control group (p<0.01). All the treatment groups can encourage Gene-Bcl2 expression in the rats' myocardial obviously in contrast to the model group (p<0.05 or p<0.01).Among those groups high-dose LiXin I group is superior to the other treatment groups obviously (p<0.05 or p<0.01).Conclusions:1. It can inhabit protein-Bax expression and encourage protein-Bcl-2 expression with LiXin I and so it is possible to reverse ventricular remodeling through taking part in myocardial... |
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