The Effects Of Hypoxia On The Coagulation System Of The Low Birth Weighe Infant

Objectives: With advancing technology, the survival rate of the hypoxic newborns and low birth weight infants (LBW) have been improved. On the other hand, the apparatus of these high risk infant are immature, the coagulation system maintains balance at low level in neonate, and neonate is easy to be infected, the clinic treatments such as arterpuncture and veinpunture can destroy the hemostasia and coagulation system et al, so hemorrhagic rate of newborn is higher than children's. Asphyxia usually occurs in neonate, and it can make the newborn deformity or death. VEC(vascular endothelial cells) is damaged when asphyxia occurs, then superoxidized enzyme and the factors of inflammation are released, prostaglandin is decreased, and platelet-actived factor is increased. These pathological processes can active coagulation pathway, destroy the balance of coagulation systerm, arose bleeding. In this study, we investigate the coagultion characteristic of the LBW and asphyxia neonate, supply the basis for clinical treatment and prevention.Methods: The 43 neonate who suit our test were collected in NICU of Qilu hospital. The neonate are all low birth weight infants(LBW),include 10 preterm infants without asphyxia,23 asphyxia preterm infants and 10 asphyxia full term infant. The weight of all these infants is between 1500g ~ 2500g.The control group include 30 infants who arecollected from delivery room in our hospital. Vein blood of all infants were collected in 24 hours after born. The blood are entered the especial pipe with anticoagulation reagent, and delivered to hemostasis and thrombus room, tested with completed autom-cruor appearance of Instrumentation Laboratory. Collect sample after treatment with vitamin K, the means is same to before. All data dealedwith SPSS 11.5.The results expressed by x ±s. T test and Wilcoxon signed rank test are used in analysis of the data.Results: l.The coagulation function of natural full term infants is different from the function of LBW.2.There is difference between the full term infants without asphyxia group and the full term infants with asphyxia. The level of coagulation is different between the group of the preterm infants without asphyxia and the group of with asphyxia.3.After treatment with vitamin K, the coagulation functions of asphyxia neonate and LBW are improved.4. The curative effect of vitamin K is different between full term infants with asphyxia and preterm infants with asphyxia.Conclusions: From the test, we can study that the level of coagulation function in LBW is lower than the normal weight infants, and asphyxia can destroy the coagulation function. And we can find vitamin K can improve the coagulation function. But in preterm infants, the curative effect is not perfect, so we should attach importance to the clinical treatment and prevention of the preterm infants.