Expression And Secretion Of Calcitonin Gene-Related Peptide In Lesions Of Different Stages Of Psoriasis

ObjectivesIn order to study the mechanism of the effect of stress on psoriasis and the involvement of neuropeptides in psoriatic pathogenesis, we investigated the expression and secretion of calcitonin gene-related peptide (CGRP) in lesions of different stages of psoriasis and identified the chance of CGRP effective nerve fibers.Metheds50 biopsies of lesional skin of patients with psoriasis vulgaris were employed in this study, and we departed that into four groups by different stage lesions of psoriasis. 15 biopsies of healthy skin served as normal control.Immuno-histochemical SP method was employed in the experiments. Wilcoxon rank sum test and Student' s t-test were employed for statistical analysis.ResultsStaining with intensity from ++ to +++ was oberserved in lesions of active and stable psoriasis, + to +++ in recovery patients and non-lesional skin of stable psoriasis, mainly in epidermal and papillary dermis. Staining with intensity from + to ++ was oberserved in partial normal controls. There was a significant overexpression of CGRP in lesions of active and stable psoriasis comparing with that in recovery patients and normal cases (p<0.01). The expression of CGRP in lesions of stablepsoriasis was over than that in active patients(p<0. 01). There was a higher amount of papillary dermal nerve fibers in psoriasis lesional skin . Quantification of papillary dermal nerve fiber: The length of nerve fibers in psoriasis lesional skin was much longer than in normal controls(p<0.05).The length of nerve fibers in stable psoriasis was longer than in active psoriasis(p<0. 05).ConclusionsThere was a significant overexpression of CGRP in lesions of active and stable psoriasis. There was a higher amount of papillary dermal nerve fibers in psoriasis lesional skin . The expression of CGRP in lesions of different stages of psoriasis was different. The results indicated that CGRP not only took part in the occurrence and development of psoriasis, but also played an important role in the lasting phase of this disease, and that the regulations of nerve system in the psoriatic lesions was partly through CGRP.