Expression And Significance Of COX-2 And VEGF In Transitional Cell Carcinoma Of Human Bladder

Objectivs: To study the expression of COX-2 and VEGF in human BTCC, andexplore their significance.Methods: SP two-steps immunohistochemistry was applied to detect the ex-pression of COX-2 and VEGF in 70 BTCC tissues, and in 18 benign bladderdiseases. And analyse the relationships between the expression and theclinico-pathologic parameters .Results: The positive expression of COX-2 and VEGF were mianly distributedin tumor cell cytoplasm, the positive rates were as follow:72.9%( COX-2),64.3% (VEGF),which were all significantly higher than in18benign bladder diseases (p <0.01). Expression of COX-2 and VEGF in groupof tumor diameter ≥4.1cm was stronger than in group<4.1cm(bothp<0.05).The expression of COX-2 and VEGF showed no significantrelationships between the initial and recrudescent BTCC, yet between thesingle and multiple BTCC. COX-2 was significantly related to the WHOGrade (p=0.041) and pTNM Stage(p<0.01) . G₁ was Signi-ficantly correlatedwith G3 (p <0.01).The COX-2 level of in Pis + pTa was markly lower thanother stages(p <0.01). pT₁ tumor showed almost same level of COX-2 withpT₂(p =0.960).The positive rates of VEGF in different Grades were asfollow:54.5%(G₁),65%(G₂),87.5% (G₃). Expression of VEGF in G₃ was signi-ficantly stronger than in G₁ and G₂ . VEGF was no related to pTNM Stage(p=0.052). pT₂ was significantly correlated with Pis+pTa (p=0.007).VEGF haspositive correlation with COX-2(r=0.456,p<0.01).By single factor analysis,no association was noted between COX-2 or VEGF with the recurrence inBTCC。Conclusions: COX-2 was related to the growth, grade and stage in human BTCC.VEGF has relation with the growth and grade,has positive correlation withCOX-2. COX-2 and VEGF both were not indepent prognostic factors ofrecurrence in human BTCC.