Pyridinoline Cross-linked Carboxyterminal Telopeptide Of Type I Collagen (ICTP) In Gingival Crevicular Fluid During Orthodontic Tooth Movement

The aim of the study was to examine the pyridinoline cross-linked carboxyterminal telopeptide of type â…  collagen (ICTP) in gingival crevicular fluid (GCF) to learn whether alveolar bone remodeling could be monitored during orthodontic tooth movement. Thirteen individuals undergoing fixed orthodontic treatment involving maxillary anterior teeth alignment were enrolled in the study. The GCF around the experimental teeth was harvested 1wk before appliance activation and weekly over the following 4 weeks. Following GCF collecting, probing depth, plaque index and bleeding on probing at selected experimental teeth was also recorded. GCF ICTP levels were quantified using radioimmunoassay(RIA). The GCF volumes and ICTP levels increased significantly at lwk after the experiment had begun. Both GCF volumes and ICTP levels decreased at a later stage of tooth movement cycle. The results of this study suggested that ICTP levels in GCF reflected the biologic activity in the periodontium during orthodontic movement which was characterized by periods of activation, resorption, reversal, and formation.